Author： Baka I.D. Ninkina N.N. Pinon L.G.P. Adu J. Davies A.M. Georgiev G.P. Buchman V.L.
Publisher： Academic Press
ISSN： 1044-7431
Source： Molecular and Cellular Neuroscience, Vol.7, Iss.4, 1996-04, pp. : 289-303
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Abstract
Using a subtractive hybridization technique directed to cloning transcripts with compartmentalized distributions within cerebral cortex neurons, we have isolated rat s-rex mRNAs that are analogues of the human neuroendocrine-specific NSP gene transcripts. Differential splicing produces two main s-rex mRNA that have different regional distributions in the developing and mature rat nervous system. In certain populations of adult brain neurons, most of s-rex s mRNA and a substantial amount of s-rex b mRNA are localized to the axonal pole of the cell body. The localization of S-Rex/NSP proteins in these neurons suggests that s-rex mRNA compartmentalization targets the encoded proteins to specific regions of the neuron.
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