Author: Heckman C.A. Boxer L.M.
Publisher: Academic Press
ISSN: 1046-2023
Source: Methods, Vol.26, Iss.1, 2002-01, pp. : 19-26
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
In vivo footprinting techniques are useful for the identification of regulatory elements mediating transcriptional control of a gene. However, regulation of a gene can differ between the two alleles, and further steps must be taken to distinguish between the regulatory elements occupied on one allele and those used on the second allele. Many hematologic malignancies result from chromosomal translocations, which, in some cases, relocate a gene to a transcriptionally active region leading to the deregulated expression of that gene. This situation provides an example of differential expression between two alleles. In studying the t(14; 18) and t(8; 14) translocations, which involve the
Related content
Thyroid-specific transcription factors control Hex promoter activity
By Damante G.
Nucleic Acids Research, Vol. 31, Iss. 7, 2003-04 ,pp. :
By Regec A.L. Quadros E.V. Rothenberg S.P.
Archives of Biochemistry and Biophysics, Vol. 407, Iss. 2, 2002-11 ,pp. :
By Nilsson Maria Dahlman-Wright Karin Karelmo Charlotta Ebeling Martin Gustafsson Jan-Åke Steffensen Knut R.
Nucleic Acids Research, Vol. 36, Iss. 1, 2008-01 ,pp. :