Author： Ye F.Q. Smith A.M. Mattay V.S. Ruttimann U.E. Frank J.A. Weinberger D.R. McLaughlin A.C.
Publisher： Academic Press
ISSN： 1053-8119
Source： NeuroImage, Vol.8, Iss.1, 1998-07, pp. : 44-49
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Abstract
Steady-state arterial spin-tagging MRI approaches were used to quantitate regional cerebral blood flow increases in prefrontal cortex during a working memory (“two-back”) task in six normal subjects. Statistically significant increases in cerebral blood flow in prefrontal cortex were observed in all six subjects: the average increase in cerebral blood flow in activated prefrontal cortex regions was 22 ± 5 cc/100 g/min (23 ± 7%). The results demonstrate that spin-tagging approaches can be used to follow focal activation in prefrontal cortex during cognitive tasks.
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