Enhanced Levels of Soluble VCAM-1 in Sickle Cell Patients and Their Specific Increment during Vasoocclusive Crisis

Author: Duits A.J.   Pieters R.C.   Saleh A.W.   van Rosmalen E.   Katerberg H.   Berend K.   Rojer R.A.  

Publisher: Academic Press

ISSN: 1521-6616

Source: Clinical Immunology, Vol.81, Iss.1, 1996-10, pp. : 96-98

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Abstract

Adhesion of sickle erythrocytes to vascular endothelium plays a central role in sickle cell disease complications. Cytokines and adhesion molecules are critically involved in the regulation of these adhesive processes. To analyze their role, IL-6, GM-CSF, sVCAM-1, sICAM-1, sE-Selectin, and sP-Selectin serum levels were determined in sickle cell patients under basic conditions and during vasoocclusive crisis. In nonsymptomatic patients a high serum level of sVCAM-1 was observed compared to controls. In patients having vasoocclusive crisis sVCAM-1 levels increased even more and seemed to correlate with crisis evolution.

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