Transforming growth factor-β1 induced hepatocyte apoptosis

Author： Hayashi Hikota Kohno Hitoshi Ono Takashi Yamanoi Akira Dhar Dipok Ueda Shuhei Rahman Mohammad Kubota Hirofumi Nagasue Naofumi

Publisher： Informa Healthcare

ISSN： 0284-186X

Source： Acta Oncologica, Vol.43, Iss.1, 2004-03, pp. : 91-97

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Abstract

The mechanisms of colonization and growth of metastatic liver tumors from colorectal cancers remain obscure. Forty-three resected colorectal metastatic liver tumors with surrounding livers were evaluated for apoptotic index (AI), proliferation index (PI), and immunohistochemical expressions of TGF-β1, TGF-β receptor II, Fas, and Fas-ligand. All the parameters were significantly higher in the peri-tumoral livers than in the tumors with the exception of PI, which was significantly high in tumors. Enhanced TGF-β1 expression was noticed at the interface between the metastatic tumor and the adjacent liver parenchyma. The AIs of hepatocytes in the TGF-β1-positive areas (8.7±7.5%, n=43) were significantly higher when compared with those in the TGF-β1-negative areas (2.4±4.5%, n=42) (p<0.001). However, the same kind of correlation could not be found in metastatic tumors. The enhanced expression of TGF-β1 and hepatocyte apoptosis in the peri-tumoral liver parenchyma may suggest that TGF-β1 plays a substantial role in the development of colorectal liver metastasis.