Author: Katz N. P. Buse D. C. Budman S. H. Wing Venuti S. Fernandez K. C. Benoit C. Bianchi R. Cooper D. Jasinski D. R. Smith D. E. Butler S. F.
Publisher: Informa Healthcare
ISSN: 0363-9045
Source: Drug Development and Industrial Pharmacy, Vol.32, Iss.6, 2006-06, pp. : 727-746
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Abstract
One important factor in the abuse potential of an opioid product is the ease with which active drug can be extracted. There are currently no standards for testing or reporting extractability. This article describes the development of an Extractability Rating System for use by the pharmaceutical industry and regulators. Despite several limitations, this effort serves as a call for standardized testing and reporting so that products can be accurately rated, and should help establish goals for drug developers who wish to develop “abuse-resistant” opioid products.
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