Author： Nettey Henry Haswani Dinesh D'Souza Martin Oettinger Carl
Publisher： Informa Healthcare
ISSN： 0363-9045
Source： Drug Development and Industrial Pharmacy, Vol.33, Iss.2, 2007-02, pp. : 133-139
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Abstract
Vancomycin (VCN) is a glycopeptide antibiotic that is effective in the treatment of gram-positive bacterial infections, but mainly reserved for methicilin resistant Staphylococcus aureus. It is, however, ineffective against intracellular bacteria and hence a particulate form of VCN would be required. Bovine serum albumin (BSA) microspheres of VCN with a mean particle size of 5 ± 1.6 μm were used. Human microvascular endothelial cells internalized both S. aureus and VCN microspheres in a time and concentration-dependent manner, however, the uptake was inhibited by cytochalasin D. Action of VCN on S. aureus in the intracellular microenvironment decreased the bacterial load considerably.
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By Haswani D. K. Nettey H. D'Souza M. J. Oettinger C. W.
Drug Development and Industrial Pharmacy, Vol. 33, Iss. 2, 2007-02 ,pp. :