Author： Guzman Valeska Silva Ismael Brenna Sylvia Carvalho Carmen Ribalta Julisa Gerbase-DeLima Maria
Publisher： Informa Healthcare
ISSN： 0735-7907
Source： Cancer Investigation, Vol.26, Iss.5, 2008-06, pp. : 499-503
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Abstract
The present study assessed, in cervical carcinoma, expression levels of seven immune response genes and sought correlation to response to treatment. The expression levels of CD28, CTLA4, ICOS, ICOSL, CD80 and CD86 and granzyme B genes were assessed by real-time RT-PCR in pre-treatment tumor fragments. During the six-month follow-up after treatment, 8 patients presented tumor and 10 survived free of tumor. The only gene whose expression levels were higher in patients with poor outcome (p = 0.03) was granzyme B. Further evaluation, in adequately powered prospective studies is warranted to confirm the data and to translate this observation to the clinical setting.
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