Author： Gomez-Flores R. Verastegui-Rodriguez L. Quintanilla-Licea R. Tamez-Guerra P. Monreal-Cuevas E. Tamez-Guerra R. Rodriguez-Padilla C.
Publisher： Informa Healthcare
ISSN： 0735-7907
Source： Cancer Investigation, Vol.27, Iss.2, 2009-02, pp. : 149-155
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Abstract
The present study was undertaken to validate the antitumor potential of Gymnosperma glutinosum from regional people's account, using the in vitro and in vivo L5178Y-R lymphoma murine model. Non-polar G. glutinosum crude extracts were tested on L5178Y-R cells. We found significant (p < 0.05) cytotoxic activity (up to 40%) of the hexane extract, which was further fractioned; fraction 1 (F1) was then observed to produce up to 51% apoptosis-mediated L5178Y-R cytotoxicity in vitro at concentrations lower than 0.98 μ g/ml, and possess significant in vivo antitumor activity. This study may support further evaluation of active F1 in clinical trials.
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