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Prognostic Value of the t(14;18)(q32;q21) in Patients With Diffuse Large B-Cell Lymphoma

Author： Abdel-Ghaffar Hasan   El-Aziz Sherin Abd   Shahin Doaa   Degheidy Heba   Selim Tarek   Elsobky Ezzat   Attwan Nadia   Al-Tonbary Youssef A.  

Publisher： Informa Healthcare

ISSN： 0735-7907

Source： Cancer Investigation, Vol.28, Iss.4, 2010-04, pp. : 376-380

Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.

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Abstract

ABSTRACTThe prognostic significance of the t(14;18) in diffuse large B-cell lymphoma is still controversial. To assess the impact of the t(14;18) on patient survival, we investigated 26 patients with diffuse large B-cell lymphoma for the presence of t(14;18). The t(14;18) was detected in 90.9% of patients with high international prognostic index score. The five-year overall survival was 0.0% and 68.75% in positive and negative cases of t(14;18) respectively. The detection of the t(14;18) combined with the international prognostic index score is a useful strategy for more appropriate risk stratification and prediction of outcome of patients with diffuse large B-cell lymphoma.

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