Icb-1 Gene Expression is Elevated in Human Endometrial Adenocarcinoma and is Closely Associated With HER2 Expression

Author： Springwald Anette   Lattrich Claus   Skrzypczak Maciej   Goerse Regina   Ortmann Olaf   Treeck Oliver  

Publisher： Informa Healthcare

ISSN： 0735-7907

Source： Cancer Investigation, Vol.28, Iss.9, 2010-10, pp. : 904-909

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Abstract

ABSTRACTHuman gene Icb-1 (C1orf38) has been initially cloned by our group from endometrial adenocarcinoma cells. In this study, we examined Icb-1 expression in 90 endometrial cancer and normal endometrial tissue specimens. Expression of Icb-1 was significantly (about 3.5-fold) higher in endometrial cancer than in normal endometrium (p <.0001). Determination of various molecular markers revealed that only Ki-67 expression differed between both groups in a similarly significant manner. Furthermore, we observed a highly significant positive correlation of Icb-1 transcript levels with c-erbB2 (HER2) expression (p <.0001). Our data strongly encourage further studies on the function of Icb-1 in endometrial cancer.

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