Author： Hercus Timothy R. Broughton Sophie E. Ekert Paul G. Ramshaw Hayley S. Perugini Michelle Grimbaldeston Michele Woodcock Joanna M. Thomas Daniel Pitson Stuart Hughes Timothy D'Andrea Richard J. Parker Michael W. Lopez Angel F.
Publisher： Informa Healthcare
ISSN： 0897-7194
Source： Growth Factors, Vol.30, Iss.2, 2012-04, pp. : 63-75
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a pluripotent cytokine produced by many cells in the body, which regulates normal and malignant hemopoiesis as well as innate and adaptive immunity. GM-CSF assembles and activates its heterodimeric receptor complex on the surface of myeloid cells, initiating multiple signaling pathways that control key functions such as cell survival, cell proliferation, and functional activation. Understanding the molecular composition of these pathways, the interaction of the various components as well as the kinetics and dose-dependent mechanics of receptor activation provides valuable insights into the function of GM-CSF as well as the related cytokines, interleukin-3 and interleukin-5. This knowledge provides opportunities for the development of new therapies to block the action of these cytokines in hematological malignancy and chronic inflammation.
Related content
By Meyer Johann Laker Christine Janzir Nadia Franz Marie-Joseé Bergholz Ursula Ostertag Wolfram Stocking Carol
Growth Factors, Vol. 20, Iss. 3, 2002-01 ,pp. :
Access to resources
Recommend
By Löhrke B. Shahi S.K. Krüger B. Schmidt P. Renne U. Dietl G.
Pflügers Archiv, Vol. 439, Iss. 3, 2000-01 ,pp. :
On the activation mechanism of store-operated calcium channels
By Parekh Anant
Pflügers Archiv, Vol. 453, Iss. 3, 2006-12 ,pp. :