Basic Autonomic Nervous Function in Patients with Neurocardiogenic Syncope

Author: Saito Fumio   Imai Shinobu   Tanaka Nobuyuki   Tanaka Hideyuki   Suzuki Kazutaka   Takase Hidehito   Aoyama Hiroshi   Matsudaira Kagari   Ebuchi Tomonori   Akamine Yasuyuki   Takahashi Naoyuki   Sugino Keiichi   Kanmatsuse Katsuo   Yagi Hiroshi   Kushiro Toshio  

Publisher: Informa Healthcare

ISSN: 1064-1963

Source: Clinical and Experimental Hypertension, Vol.29, Iss.3, 2007-03, pp. : 165-173

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Abstract

Basic autonomic nervous function was evaluated in patients with neurocardiogenic syncope (NCS). Atropine, isoproterenol, propranolol, phenylephrine, and phentolamine were administered successively, and parasympathetic nerve activity and β- (and α-) activity, sensitivity, and secretion of the sympathetic nerve were determined in patients with NCS and control subjects. In patients with NCS, β- and α- sensitivity were higher and β-activity and β- and α-secretion lower than in control subjects. In patients with NCS, the increased basic β-sensitivity may contribute to induce strong cardiac contractions and augment ventricular mechanoreceptor response, and a compensatory state against diminished neuronal sympathetic activity is suggested by the increased α-sensitivity.