Effect of combined coenzyme Q10 and d-  -tocopheryl acetate supplementation on exercise-induced lipid peroxidation and muscular damage: a placebo-controlled double-blind study in marathon runners

Author： Kaikkonen Jari Kosonen Lotta Nyyssönen Kristiina Porkkala-Sarataho Elina Salonen Riitta Korpela Heikki Salonen Jukka

Publisher： Informa Healthcare

ISSN： 1071-5762

Source： Free Radical Research, Vol.29, Iss.1, 1998-01, pp. : 85-92

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Abstract

To test the effects of combined coenzyme Q10 (Q10) and d-  -tocopheryl acetate supplementation on exercise-induced oxidative stress and muscular damage we conducted a double-blind study in 37 moderately trained male marathon runners. These were randomly allocated to receive either an antioxidant cocktail: 90 mg of Q10 and 13.5 mg of d-  -tocopheryl acetate daily (18 men) or placebo (19 men) for three weeks before a marathon (42 km) run. Just before the run, plasma Q10 was 282% ( p - of LDL and the increased susceptibility of lipoproteins to copper induced oxidation. However, the supplementation had no effect on lipid peroxidation or on the muscular damage (increase in serum creatine kinase activity or in plasma lactate levels) induced by exhaustive exercise. Plasma ascorbate, Q10, whole blood glutathione and serum uric acid concentrations increased during the exercise, elevating significantly the TRAP value of plasma by 10.3% and the proportion of plasma ubiquinol of total Q10 by 4.9%. These results suggest that even though exercise increases plasma lipid peroxidation, it also elevates the antioxidative capacity of plasma, as assessed by the increased plasma TRAP and the proportion of Q10H 2 of total Q10. However, prior supplementation with small doses of Q10 and d-  -tocopheryl acetate neither attenuates the oxidation of lipoproteins nor muscular damage induced by exhaustive exercise such as encountered in a marathon run.