Author: Krauskopf Alexandra Lhote Philippe Petermann Olivier Ruegg Urs T. Buetler Timo M.
Publisher: Informa Healthcare
ISSN: 1071-5762
Source: Free Radical Research, Vol.39, Iss.9, 2005-09, pp. : 913-919
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
Cyclosporin A (CsA) generates superoxide in smooth muscle cells. Our earlier studies have demonstrated that the increase in the vasopressin type 1 receptor induced in vascular smooth muscle cells in the presence of CsA is probably due to superoxide (Krauskopf et al., J Biol Chem 278, 41685–41690, 2003). This increase in vasopressin receptor is likely at the base of increased vascular responsiveness to vasoconstrictor hormones and hypertension induced by CsA. Here, we demonstrate that CsA produces superoxide. In addition, our data show that superoxide generation does not originate from the major cellular superoxide generating systems NAD(P)H oxidase or xanthine oxidase. Our results suggest that the side effects of CsA could be diminished with the help of SOD mimetic drugs.
Related content
By Sutra Thibault Morena Marion Bargnoux Anne-Sophie Caporiccio Bertrand Canaud Bernard Cristol Jean-Paul
Free Radical Research, Vol. 42, Iss. 9, 2008-09 ,pp. :
By Nguyen N.S.D. Cottet-Maire F. Buetler T.M. Lo Russo A. Krauskopf A.S. Armstrong J.M. Vickers A.E.M. Mace K. Ruegg U.T.
Free Radical Biology and Medicine, Vol. 27, Iss. 11, 1999-12 ,pp. :
By Nishimura Masashi Ookawara Tomomi Eguchi Hironobu Fujiwara Noriko Yoshihara Daisaku Yasuda Jun Mimura Osamu Suzuki Keiichiro
Free Radical Research, Vol. 40, Iss. 6, 2006-06 ,pp. :
Biochemical and Biophysical Research Communications, Vol. 259, Iss. 2, 1999-06 ,pp. :
By Privat C. Stepien O. David-Dufilho M. Brunet A. Bedioui F. Marche P. Devynck J. Devynck M.-A.
Free Radical Biology and Medicine, Vol. 27, Iss. 5, 1999-09 ,pp. :