Interactions between the OGG1 Ser326Cys polymorphism and intake of fruit and vegetables in relation to lung cancer

Author: SØrensen Mette   Raaschou-Nielsen Ole   Hansen Rikke D.   TjØnneland Anne   Overvad Kim   Vogel Ulla  

Publisher: Informa Healthcare

ISSN: 1071-5762

Source: Free Radical Research, Vol.40, Iss.8, 2006-08, pp. : 885-891

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Abstract

The enzyme 8-oxoguanine glycosylase 1 (OGG1) repairs oxidatively damaged DNA and a polymorphism in the OGG1 gene (Ser 326 Cys) has been associated with lung cancer. We examined associations between the polymorphism and intake of fruits and vegetables and smoking in the development of lung cancer, by genotyping blood samples from 431 lung cancer cases and 796 comparison persons, which were identified within a prospective cohort on 57,000 cohort members. We found no overall association between the OGG1 polymorphism and lung cancer. There was a statistically significant interaction between the polymorphism and dietary intake of vegetables, with a 54% decrease in lung cancer risk per 50% increase in vegetable intake among homozygous Cys 326 Cys carriers and no decrease in risk among carriers of Ser 326 Ser or Ser 326 Cys. The same tendency was seen in relation to intake of fruit. There were no statistically significant interactions between the OGG1 polymorphism and smoking.

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