P3a Amplitude Predicts Successful Treatment Program Completion in Substance-Dependent Individuals

Author： Anderson Nathaniel E.   Baldridge Robyn M.   Stanford Matthew S.  

Publisher： Informa Healthcare

ISSN： 1082-6084

Source： Substance Use & Misuse, Vol.46, Iss.5, 2011-03, pp. : 669-677

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Abstract

This study examined P3a amplitude as a direct predictor of treatment success for substance dependence. Participants were 35 adults (27 men, 8 women) undergoing treatment for substance dependence at an urban residential treatment facility between October 2005 and July 2007. Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR) criteria were used to confirm substance dependence. P3a amplitude was significantly smaller for those who dropped out of treatment. Discriminant function analysis confirmed that P3a amplitude was a robust predictor of treatment completion, more sensitive than other measures including substance abuse severity. Implications for the interpretation of P3a amplitude as an index of executive function are discussed.

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