Author： Jay Steven Peevy Nolan Jenkins Thomas Burg Karen
Publisher： Informa Healthcare
ISSN： 1083-7450
Source： Pharmaceutical Development and Technology, Vol.11, Iss.4, 2006-12, pp. : 485-491
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Abstract
Despite its abundance in their diet, cattle are unable to directly digest cellulose. The bovine digestive tract overcomes this problem via the rumen, a portion of the stomach containing mixed anaerobic bacteria. These microbes, while breaking down foodstuffs, also perform undesirable processes such as biohydrogenation, in which unsaturated fatty acids become saturated, with deleterious cardiovascular effects. An approach to preventing this saturation entailing the use of polymeric microspheres to encapsulate feed supplements is proposed, with a single emulsion, solvent evaporation method used to formulate poly(D,L-lactide) microparticles for delivery of unsaturated fatty acids to ruminant abomasum.
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