Evaluation of WO2012078210 – development process for the preparation of a DP2 receptor antagonist; Ironwood's first development DP2 antagonist

Author: Norman Peter  

Publisher: Informa Healthcare

ISSN: 1354-3776

Source: Expert Opinion on Therapeutic Patents, Vol.22, Iss.10, 2012-10, pp. : 1257-1261

Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.

Previous Menu Next

Abstract

This application claims processes for the preparation of a series of pyrrole-based DP2 receptor antagonists, in particular 2-[3-cyano-2,5-dimethyl-4-[(2-pyrrolidin-1-ylsulfonylphenyl)methyl]pyrrol-1-yl]acetic acid. The nature of the filing points to this compound being a development compound and it may be IW-1221 which has previously been identified as a DP2 antagonist.