Cyclopeptamine lipopeptide antifungal agents

Author: Ganguly D.   Rodriguez M.J.  

Publisher: Informa Healthcare

ISSN: 1354-3776

Source: Expert Opinion on Therapeutic Patents, Vol.9, Iss.1, 1999-01, pp. : 67-71

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Abstract

A solid phase mediated automated process was developed and used by researchers at Abbott laboratories to synthesise structurally diverse amino-lipopeptides as antifungal compounds. The cyclopeptamine analogues produced by this method possess an amino or substituted amino functionality in the proline ring (A) (Figure 2). These amino-lipopeptides have good in vitro and in vivo antifungal activity against Candida albicans.