Author： Peters A.
Publisher： Informa Healthcare
ISSN： 1354-3776
Source： Expert Opinion on Therapeutic Patents, Vol.9, Iss.9, 1999-09, pp. : 1165-1171
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Abstract
Functional imaging contributes to the acquisition of fundamental biomedical knowledge, to routine patient management and to clinical research, including drug development. Functional imaging may ultimately makes its greatest impact in the context of drug development. Whilst nuclear medicine, including single-photon gamma camera imaging and, increasingly, positron emission tomography, is still the most important functional imaging technique, other radiological techniques, including magnetic resonance imaging, computerised tomography and functionally targeted ultrasonography, are all gaining ground. Within the context of drug development, functional imaging may be used to address questions in relation to 1) basic mechanism of disease; 2) pharmacokinetics of new drugs; 3) assessment and quantification of drug efficacy; 4) mechanism of drug action; and 5) the identification of patients most likely to respond to a specific drug. Within the interests of the pharmaceutical industry, the pathologic subgroups most extensively studied are likely to include inflammatory disease, oncology, vascular disease and neuropsychiatric disorders. In order to most effectively exploit functional imaging in drug development, pharmaceutical companies should become more closely associated with academic imaging institutions and with imaging experts who are encouraged to retain their academic affiliations.
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