Author： Bettega D. Calzolari P. Marchesini R. Chiorda G. L. Noris Piazzolla A. Tallone L. Cera F. Cherubini R. Vecchia M. Dalla Favaretto S. Tiveron P.
Publisher： Informa Healthcare
ISSN： 1362-3095
Source： International Journal of Radiation Biology, Vol.73, Iss.3, 1998-03, pp. : 303-309
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
Purpose: To determine the RBE-LET relationship for C3H10T1/2 cell inactivation by protons in the LET range 11-33 keV/ mu m and to compare inactivation frequencies induced in C3H10T1/2 cells by protons and deuterons at two matching LET values in the range 11-20 keV/ mu m. Materials and methods: C3H10T1/2 cells were irradiated with protons and deuterons at the radiobiological facility set up at the 7 MV Van de Graaff accelerator at the LNL, Legnaro, Padova. Gamma rays from 60Co were used as reference radiation. Results: Proton RBE values ( alpha / alpha c ) for inactivation of C3H10T1/2 cells are constant around a value of 2 between 11 and 20 keV/ mu m and then rise sharply to reach a value of 4.2 1.0 at 33 keV/ mu m. Deuteron RBE values are 1.7 0.4 and 2.2 0.6 at LET values of 13 and 18 keV/ mu m respectively. Conclusions: Proton RBE values with C3H10T1/2 cells are significantly larger than unity at LET values as low as 11 keV/ mu m. No difference in effectiveness for inactivation of C3H10T1/2 has been found between protons and deuterons at two LET values in the range 10-20 keV/ mu m.
Related content
Access to resources
Recommend
By Goodhead D.T. Belli M. Mill A.J. Bance D.A. Allens L.A. Hall S.C. Ianzani F. Simone G. Stevens D.L. Stretch A. Tabocchini M.A. Wilkinson R.E.
International Journal of Radiation Biology, Vol. 61, Iss. 5, 1992-05 ,pp. :
By Bettega D. Calzolari P. Lombardi L. Tallone
International Journal of Radiation Biology, Vol. 52, Iss. 5, 1987-11 ,pp. :