Author： Schwartz J. L. Rasey J. Wiens L. Jordan R. Russell K. J.
Publisher： Informa Healthcare
ISSN： 1362-3095
Source： International Journal of Radiation Biology, Vol.75, Iss.3, 1999-03, pp. : 285-291
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Abstract
Purpose : To examine the effect of functional loss of p53 on radiation sensitivity and potentially lethal damage repair (PLDR). Materials and methods : Radiation sensitivity and PLDR were examined in an isogenic pair of human tumour cell lines created by HPV- E6 transformation. Results : Inactivation of p53 by E6 transformation resulted in a cell line that was more resistant to killing by radiation but showed little enhancement in survival (PLDR) when plateauphase cells were held non-cycling after radiation exposure. Holding p53 -normal cells in plateau-phase after radiation exposure not only led to enhanced survival, but also to a reduction in the proportion of cells that blocked in G1 subsequent to release. Conclusions : These results suggest that p53 expression influences that component of radiation sensitivity associated with PLDR.
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