Homocysteine, folate and pregnancy outcomes

Author: Kim M. W.   Hong S.-C.   Choi J. S.   Han J.-Y.   Oh M.-J.   Kim H. J.   Nava-Ocampo A.   Koren G.  

Publisher: Informa Healthcare

ISSN: 1364-6893

Source: Journal of Obstetrics & Gynaecology, Vol.32, Iss.6, 2012-08, pp. : 520-524

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Abstract

The purpose of this study is to evaluate the relationship between maternal and/or cord blood folate/homocysteine concentrations and adverse pregnancy outcomes. The study population included a random sample of singleton pregnant women in whom we measured total homocysteine and folic acid in maternal or cord blood at deliveries. A total of 227 pregnant women were enrolled. The concentration of folate in maternal blood tended to be significantly lower in pre-term birth than in full-term delivery group (median (95% CI), 14.4 (3.6–73) vs 25 (7.3–105.5) p < 0.01). The total homocysteine in maternal and cord blood was significantly higher in the pre-eclampsia than in the normotensive group (7.9 (1.7–28.2) vs 5.9 (1.8–14.6) μmol/ml, p < 0.05; and 5.8 (2.6–14.4) vs 4.2 (0.7–7.9) ng/ml, p < 0.05, respectively). Lower maternal serum folate concentration is associated with pre-term delivery and higher maternal plasma homocysteine concentration with pre-eclampsia.

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