Author： Hu Y. Zhou Z. Xue X. Li X. Fu J. Cohen B. Melikian A. A. Desai M. Tang M.-S. Huang X. Roy N. Sun J. Nan P. Qu Q.
Publisher： Informa Healthcare
ISSN： 1366-5804
Source： Biomarkers, Vol.11, Iss.4, 2006-07, pp. : 306-318
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Abstract
The study was conducted in a Chinese population with occupational or environmental exposures to polycyclic aromatic hydrocarbons (PAHs). A total of 106 subjects were recruited from coke-oven workers (workers), residents in a metropolitan area (residents) and suburban gardeners (gardeners). All subjects were monitored twice for their personal exposures to PAHs. The biological samples were collected for measurements of 1-hydroxypyrene (1-OHP) and cotinine in urine. The geometric means of personal exposure levels of pyrene, benz(a)anthracene (BaA) and benzo(a)pyrene (BaP) in workers were 1.470, 0.978 and 0.805 µg m −3 , respectively. The corresponding levels in residents were 0.050, 0.034 and 0.025 µg m −3 ; and those in gardeners were 0.011, 0.020 and 0.008 µg m −3 , respectively. The conjugate of 1-OHP with glucuronide (1-OHP-G) is the predominant form of pyrene metabolite in urine and it showed strong associations with exposures not only to pyrene, but also to BaA, BaP and total PAHs. Most importantly, a significant difference in 1-OHP-G was even detected between the subgroups with exposures to BaP at 0.010 but
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