Molecular modelling of CYP2A enzymes: application to metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)

By Jalas J. R.   Seetharaman M.   Hecht S. S.   Murphy S. E.  

Xenobiotica, Vol. 34, Iss. 6, 2004-06 ,pp. : 515-533

Informa Healthcare

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Purification and characterization of oxidoreductases-catalyzing carbonyl reduction of the tobacco-specific nitrosamine 4-methylnitrosamino-1-(3-pyridyl)-1-butanone (NNK) in human liver cytosol

By Atalla A.   Breyer-Pfaff U.   Maser E.  

Xenobiotica, Vol. 30, Iss. 8, 2000-08 ,pp. : 755-769

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Kinetic Analysis of the Activation of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone by Heterologously Expressed Human P450 Enzymes and the Effect of P450- Specific Chemical Inhibitors on This Activation in Human Liver Microsomes

By Patten C.J.   Smith T.J.   Murphy S.E.   Wang M.H.   Lee J.   Tynes R.E.   Koch P.   Yang C.S.  

Archives of Biochemistry and Biophysics, Vol. 333, Iss. 1, 1996-09 ,pp. : 127-138

Elsevier

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Effects of Vitamins and Common Drugs on Reduction of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone in Rat Microsomes

By Leung Y.K.   Ho J.W.  

Archives of Physiology and Biochemistry, Vol. 109, Iss. 2, 2001-04 ,pp. : 175-179

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Characterization and Mapping of DNA Damage Induced by Reactive Metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) at Nucleotide Resolution in Human Genomic DNA

By Cloutier J-F.   Drouin R.   Weinfeld M.   O'Connor T.R.   Castonguay A.  

Journal of Molecular Biology, Vol. 313, Iss. 3, 2001-10 ,pp. : 539-557

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