A comparison of creatinine vs. specific gravity to correct for urinary dilution of cotinine

Author： Muscat Joshua E.   Liu Anderson   Richie John P.  

Publisher： Informa Healthcare

ISSN： 1366-5804

Source： Biomarkers, Vol.16, Iss.3, 2011-05, pp. : 206-211

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Abstract

Context: The validity of urinary correction standards has not been established for most analytes. Methods: We compared urinary creatinine and specific gravity as dilution correction standards for cotinine in a community-based study of smokers.Results: Models of blood cotinine regressed against CR or SG (measured by total soluble solids) significantly improved the fit compared to a model without a dilution measure (P < 0.01). There were no differences in model fit between CR- and SG-corrected values. Both CR and SG were significant predictors of urinary cotinine regressed against cigarettes smoked per day (P < 0.01). Conclusion: CR and SG are valid and interchangeable correction standards.

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