Author： Ogawa Tsuneo de Bold Adolfo J.
Publisher： Informa Healthcare
ISSN： 1366-5804
Source： Biomarkers, Vol.17, Iss.2, 2012-03, pp. : 140-149
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
We investigated the expression and secretion of the natriuretic peptides (NPs) ANF and BNP in lipopolysaccharide (LPS)-induced sepsis and its association with cytokines and other biologically active substances. LPS treatment increased plasma levels of ANF and BNP. The latter increase was larger than the increase in plasma ANF. LPS also increased cardiac content and gene expression of BNP but not of ANF. LPS treatment significantly increased gene expression cytokines, chemokines and proteases, which significantly correlated with BNP gene expression. SB203580, a p38 MAP kinase inhibitor, inhibited the elevation of BNP in plasma. The present work suggests that during inflammation, BNP gene expression and secretion is uniquely related to changes in gene expression in the absence of hemodynamic changes and hence differentiates ANF and BNP as biomarkers of cardiac disease.
Related content
By Tojo K. Sato S. Tokudome G. Ohta M. Kawaguchi Y. Sakai O. Nakagawa O. Nakao K.
Biochemical and Biophysical Research Communications, Vol. 225, Iss. 2, 1996-08 ,pp. :
Access to resources
Recommend
By Ikeda K. Tojo K. Sato S. Ebisawa T. Tokudome G. Hosoya T. Harada M. Nakagawa O. Nakao K.
Biochemical and Biophysical Research Communications, Vol. 250, Iss. 2, 1998-09 ,pp. :