Clinical significance of preoperative neutrophil-lymphocyte versus platelet-lymphocyte ratio in patients with operable colorectal cancer

Author: Kwon Hyuk-Chan   Kim Sung Hyun   Oh Sung Yong   Lee Suee   Lee Ji Hyun   Choi Hong-Jo   Park Ki-Jae   Roh Mee Sook   Kim Seung-Geun   Kim Hyo-Jin   Lee Jong Hoon  

Publisher: Informa Healthcare

ISSN: 1366-5804

Source: Biomarkers, Vol.17, Iss.3, 2012-05, pp. : 216-222

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Abstract

The objective of this study was to clarify whether the neutrophil-lymphocyte ratio (NLR) and the platelet-lymphocyte ratio (PLR) are significant prognostic markers in patients with resectable colorectal cancer (CRC). A total of 200 patients who underwent curative resection for CRC were enrolled. The NLR and PLR were positively correlated (p < 0.001). Both the NLR and PLR were shown to be good prognostic biomarkers of overall survival (OS) (p == 0.002 and p == 0.001, respectively). The PLR was an independent prognostic factor of OS based on multivariate analysis (hazard ratio, 1.971; 95% confidence interval, 1.102–3.335; p == 0.021).

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