Author： Xie H Afsharian P Terelius Y Mirghani R. A Yasar ü Hagbjörk A-L Lundgren S Hu Y Rane A Hassan M
Publisher： Informa Healthcare
ISSN： 1366-5928
Source： Xenobiotica, Vol.35, Iss.3, 2005-03, pp. : 239-251
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Abstract
The effects of cyclophosphamide (CPA) on CYP enzymes in vivo and its auto induction in rat were investigated in Wistar/Fu male rats at a single dose (40 or 200?mg?kg -1 ) or as repeated dose of 200?mg?kg -1 CPA. After a single dose of CPA, mRNAs of CYPs 2B1, 2B2, 3A2, 2C11 were significantly induced up to 220-, 6.7-, 5.0- and 5.8-fold at the low dose CPA, and 4800-, 52-, 22- and 2.5-fold at the high dose. CYP2B1/2 and CYP3A proteins were increased by 4- and 2-fold (low dose) and by 28- and 1.7-fold (high dose). CYP2C11 protein levels were not altered. Microsomal activities of CYP2B, CYP3A and 2C11 were increased by 2-, 1.8- and 1.3-fold at low dose CPA, and 3.2-, 1.7- and 1.6-fold at high dose. A significant ( p ?
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