Pre-clinical pharmacokinetics of UK-453,061, a novel non-nucleoside reverse transcriptase inhibitor (NNRTI), and use of in silico physiologically based prediction tools to predict the oral pharmacokinetics of UK-453,061 in man

Author： Allan G.   Davis J.   Dickins M.   Gardner I.   Jenkins T.   Jones H.   Webster R.   Westgate H.  

Publisher： Informa Healthcare

ISSN： 1366-5928

Source： Xenobiotica, Vol.38, Iss.6, 2008-06, pp. : 620-640

Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.

Previous Menu Next

Abstract

Related content

Species differences in the multiple-dose pharmacokinetics of the non-nucleoside reverse transcriptase inhibitor (NNRTI) UK-453,061 in animals and man: implications for safety considerations

By Walker D. K.   Davis J.   Houle C.   Gardner I. B.   Webster R.  

Xenobiotica, Vol. 39, Iss. 7, 2009-07 ,pp. : 534-543

Informa Healthcare

Access to resources Recommend Favorite

The disposition and metabolism of GW695634: A non-nucleoside reverse transcriptase inhibitor (NNRTi) for treatment of HIV/AIDS

By de Serres Mark   Moss Lee   Sigafoos James   Sefler Andrea   Castellino Stephen   Bowers Gary   Serabjit-Singh Cosette  

Xenobiotica, Vol. 40, Iss. 6, 2010-06 ,pp. : 437-445

Informa Healthcare

Access to resources Recommend Favorite

Preclinical pharmacokinetics and metabolism of a potent non-nucleoside inhibitor of the hepatitis C virus NS5B polymerase

By Giuliano C.   Fiore F.   Di Marco A.   Padron Velazquez J.   Bishop A.   Bonelli F.   Gonzalez-paz O.   Marcucci I.   Harper S.   Narjes F.   Pacini B.   Monteagudo E.   Migliaccio G.   Rowley M.   Laufer R.  

Xenobiotica, Vol. 35, Iss. 10-11, 2005-10 ,pp. : 1035-1054

Informa Healthcare

Access to resources Recommend Favorite

Urinary metabolites of a novel quinoxaline non-nucleoside reverse transcriptase inhibitor in dog, cynomolgus monkey and mini-pig

By Ismail I. M.   Dear G. J.   Mutch P. J.   Davies L. H.   Plumb R. S.   Sweatman B. C.  

Xenobiotica, Vol. 29, Iss. 9, 1999-09 ,pp. : 957-967

Informa Healthcare

Access to resources Recommend Favorite

Novel tight binding PETT, HEPT and DABO-based non-nucleoside inhibitors of HIV-1 reverse transcriptase

By D'cruz Osmond J.   Uckun Fatih M.  

Journal of Enzyme Inhibition and Medicinal Chemistry, Vol. 21, Iss. 4, 2006-08 ,pp. : 329-350

Informa Healthcare

Access to resources Recommend Favorite