CYP3A5-mediated metabolism of midazolam in recombinant systems is highly sensitive to NADPH-cytochrome P450 reductase activity

Author： Christensen Hege   Hestad Anette L.   Molden Espen   Mathiesen Liv  

Publisher： Informa Healthcare

ISSN： 1366-5928

Source： Xenobiotica, Vol.41, Iss.1, 2011-01, pp. : 1-5

Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.

Previous Menu Next

Abstract

Related content

Reconstitution Premixes for Assays Using Purified Recombinant Human Cytochrome P450, NADPH-Cytochrome P450 Reductase, and Cytochrome b5

By Shaw P.M.   Hosea N.A.   Thompson D.V.   Lenius J.M.   Guengerich F.P.  

Archives of Biochemistry and Biophysics, Vol. 348, Iss. 1, 1997-12 ,pp. : 107-115

Elsevier

Access to resources Recommend Favorite

Expression of Cytochrome P450 3A7 in Escherichia coli: Effects of 5' Modification and Catalytic Characterization of Recombinant Enzyme Expressed in Bicistronic Format with NADPH-Cytochrome P450 Reductase

By Gillam E.M.J.   Wunsch R.M.   Ueng Y.F.   Shimada T.   Reilly P.E.B.   Kamataki T.   Guengerich F.P.  

Archives of Biochemistry and Biophysics, Vol. 346, Iss. 1, 1997-10 ,pp. : 81-90

Elsevier

Access to resources Recommend Favorite

Reconstitution of the Enzymatic Activities of Cytochrome P450s Using Recombinant Flavocytochromes Containing Rat Cytochrome b5 Fused to NADPH–Cytochrome P450 Reductase with Various Membrane-Binding Segments

By Gilep A.A.   Guryev O.L.   Usanov S.A.   Estabrook R.W.  

Archives of Biochemistry and Biophysics, Vol. 390, Iss. 2, 2001-06 ,pp. : 215-221

Elsevier

Access to resources Recommend Favorite

Expression, Purification, and Physical Properties of Recombinant Flavocytochrome Fusion Proteins Containing Rat Cytochrome b5 Linked to NADPH-Cytochrome P450 Reductase by Different Membrane-Binding Segments

By Gilep A.A.   Guryev O.L.   Usanov S.A.   Estabrook R.W.  

Archives of Biochemistry and Biophysics, Vol. 390, Iss. 2, 2001-06 ,pp. : 222-234

Elsevier

Access to resources Recommend Favorite

Studies on the Interactions between Drugs and Estrogen: Analytical Method for Prediction System of Gynecomastia Induced by Drugs on the Inhibitory Metabolism of Estradiol Using Escherichia coli Coexpressing Human CYP3A4 with Human NADPH-Cytochrome P450 Reductase

By Satoh T.   Fujita K-i.   Munakata H.   Itoh S.   Nakamura K.   Kamataki T.   Itoh S.   Yoshizawa I.  

Analytical Biochemistry, Vol. 286, Iss. 2, 2000-11 ,pp. : 179-186

Elsevier

Access to resources Recommend Favorite