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Xenobiotica, Vol. 42, Iss. 10, 2012-10 ,pp. : 1009-1016

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Method for predicting human intestinal first-pass metabolism of UGT substrate compounds

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Assessment of the hepatic and intestinal first-pass metabolism of midazolam in a CYP3A drug–drug interaction model rats

By Kanazu Takushi   Okamura Noboru   Yamaguchi Yoshitaka   Baba Takahiko   Koike Masahiro  

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Evaluation of animal models for intestinal first-pass metabolism of drug candidates to be metabolized by CYP3A enzymes via in vivo and in vitro oxidation of midazolam and triazolam

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Xenobiotica, Vol. 43, Iss. 7, 2013-07 ,pp. : 598-606

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Pharmacokinetics and first-pass elimination of metoprolol in rats: contribution of intestinal first-pass extraction to low bioavailability of metoprolol

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