Author： Taiwo Oludare B. Olajide Olumayokun A. Soyannwo Olufunmilola O. Makinde J. Modupe
Publisher： Informa Healthcare
ISSN： 1388-0209
Source： Pharmaceutical Biology (Formerly International Journal of Pharmacognosy), Vol.38, Iss.5, 2000-12, pp. : 367-370
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Abstract
A methanol extract of the leaves of Chromolaena odorata was evaluated for anti-inflammatory effects in the carrageenan-induced rat paw edema model as well as for antipyretic activity in mice. The effects of the extract on intestinal transit of charcoal meal and castor oil-induced diarrhoea were also investigated. The extract (50-200 mg/kg) inhibited paw edema in rats and produced significant (p <0.05) reduction in rectal temperature of mice rendered hyperthermic by yeast suspension. Antimotility and antidiarrhoeal effects were produced by the extract in intact mice. This study establishes the out-inflammatory, antipyretic, and anti-spasmodic properties of C. odorata.
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