Author： Jimenez-Romero Carlos Ortega-Barria Eduardo Arnold A. Elizabeth Cubilla-Rios Luis
Publisher： Informa Healthcare
ISSN： 1388-0209
Source： Pharmaceutical Biology (Formerly International Journal of Pharmacognosy), Vol.46, Iss.10-11, 2008-10, pp. : 700-703
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Abstract
Three lactones were isolated from the culture medium of the endophytic fungus Xylaria sp. Grev. (Xylariaceae). The major compound, which showed weak activity (13 μ g/mL) against a chloroquine-resistant strain of Plasmodium falciparum, was identified as (+)-phomalactone (1). The others were 6-(1-propenyl)-3,4,5,6-tetrahydro-5-hydroxy-4H-pyran-2-one (2) and 5-hydroxymellein (3). Compounds 1 and 2 are reported for the first time as constituents of Xylaria. Also, this is the first report of the activity of the compounds 1-3 against a chloroquine-resistant Plasmodium falciparum strain.
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