Author： Abraham Neena S Graham David Y
Publisher： Informa Healthcare
ISSN： 1465-6566
Source： Expert Opinion on Pharmacotherapy, Vol.6, Iss.15, 2005-12, pp. : 2681-2689
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
The use of NSAIDs is associated with significant risk of upper gastrointestinal ulcer, bleeding, perforation and stricture. NSAIDs vary in their analgesic and anti-inflammatory properties; choice of NSAID, dosage and duration are the cornerstone of rationale therapy. Proton pump inhibitors are widely used to reduce the risk of serious events, despite the paucity of data that indicates that they are effective for this indication. The existing recommendations for prevention of gastrointestinal toxicity are reviewed in this article, in light of new clinical challenges posed by the emerging data regarding competing cardiovascular risk. Strategies are proposed for common clinical prescribing dilemmas, new clinical risk groups are identified and preventative strategies for these special populations are recommended.
Related content
Access to resources
Recommend
By Blandizzi Corrado Tuccori Marco Colucci Rocchina Gori Giovanni Fornai Matteo Antonioli Luca Ghisu Narcisa Mario Del Tacca
Drugs & Aging, Vol. 25, Iss. 3, 2008-01 ,pp. :
Gastrointestinal toxicity in elderly osteoarthritis patients treated with NSAIDs
By Palmer Robert H. DeLapp Ralph
Inflammopharmacology, Vol. 8, Iss. 1, 2000-03 ,pp. :