Therapeutic perspectives of adipocytokines

Author： Kralisch Susan Klein Johannes Bluher Matthias Paschke Ralf Stumvoll Michael Fasshauer Mathias

ISSN： 1465-6566

Source： Expert Opinion on Pharmacotherapy, Vol.6, Iss.6, 2005-06, pp. : 863-872

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Abstract

Various adipocyte-secreted factors have been described which profoundly affect insulin sensitivity and might potentially link obesity, insulin resistance and cardiovascular disease. Among those, adiponectin, visfatin and omentin appear as insulin-sensitising adipocytokines, whereas TNF-α, IL-6 and resistin induce insulin resistance. Moreover, leptin is a fat-derived key regulator of appetite and energy expenditure. Due to their profound effect on whole-body glucose and energy metabolism, adipocytokines have attracted interest as potential new therapeutics for diabetes mellitus and obesity. The current knowledge on f-unction, regulation and thera-peutic potential of various a-dipocytokines, as well as their clinical im-plications, are discussed in this review.