Changes in progesterone-induced-blocking-factor expression rates following mifepristone administration in termination of pregnancy at 5 to 8 weeks

Author： Salomon Laurent Rozenberg Patrick Szekeres-Bartho Julia Malagrida Lydia Giudicelli Yves Ville Yves

Publisher： Informa Healthcare

ISSN： 1476-4954

Source： Journal of Maternal-Fetal and Neonatal Medicine, Vol.17, Iss.5, 2005-05, pp. : 353-356

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Abstract

Objective. To study changes in the expression rate of PIBF by peripheral lymphocytes in healthy pregnant women after administration of mifepristone for non-surgical termination of pregnancy at 5–8 wks of gestation. Methods. Patients requesting early social termination of pregnancy, in a 3-month period, were included. A first venous blood sample was taken before oral administration of 600?mg of mifepristone (day 0). A second venous blood sample was taken 2 days later. PIBF on lymphocytes was determined by immunocytochemistry using a PIBF-specific polyclonal antibody. Results. Termination of pregnancy was successful and complete in all cases. In 17 out of 21 patients, the percentage of PIBF positive lymphocytes decreased after anti-progesterone administration. The percentage of PIBF-expressing lymphocytes significantly decreased from 52.8%?±?21.6% (day 0) to 39.8%?±?18.2% by day 2 ( p ?=?0.001). Conclusions. These data suggest a strong relationship between early termination of pregnancy induced with mifepristone and disturbances of progesterone-mediated immunosuppression.