Author： Fujimura Masaki Mizuhashi Keiichi Ishiura Yoshihisa Matsuda Tamotsu
Publisher： Informa Healthcare
ISSN： 1521-0499
Source： Experimental Lung Research, Vol.25, Iss.6, 1999-09, pp. : 467-478
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Abstract
Administration of propranolol provokes bronchoconstriction only in asthmatic patients. It is unknown whether bronchodilator therapy can prevent the propranolol-induced bronchoconstriction (PIB). We previously reported an animal model of PIB in which bronchoconstriction is caused by propranolol when inhaled 20 minutes after an antigen provocation in passively sensitized guinea pigs. Our goal was to evaluate the bronchoprotective effects of bronchodilators on the PIB in our animal model. Propranolol was inhaled 20 minutes after an antigen challenge in passively sensitized, anesthetized, and artifically ventilated guinea pigs. Atropine (5mg/kg) and equipotent doses of salbutamol (0.6ug/kg) and aminophylline (25mg/kg), which were determined by the dose-response curves for inhibition of histamine induced bronchoconstriction, were intravenously administered 5 minutes before the propranolol inhalation. Treatment of the animals with 25 mg/kg of aminophylline, but not with 0.6ug/kg of salbutamol or 5mg/kg of atropine, significantly prevented the PIB. These results show that our animal model is an experimental model of PIB which is resistant to beta2 -agonists or anticholinergics and suggest that amino-phylline may be useful to prevent and treat PIB resistant to beta2 -agonists.
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