Gastrointestinal Stromal Tumor of the Stomach with Rhabdoid Phenotype: Immunohistochemical, Ultrastructural, and Immunoelectron Microscopic Evaluation

Author： Richmond Jeffrey Mount Sharon Schwarz MDJanet

Publisher： Informa Healthcare

ISSN： 1521-0758

Source： Ultrastructural Pathology, Vol.28, Iss.3, 2004-05, pp. : 165-170

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Abstract

A variety of neoplasms with rhabdoid differentiation have been reported in many sites. The authors describe a case of gastrointestinal stromal tumor (GIST) of the stomach that exhibited prominent rhabdoid features. Immunohistochemically, the tumor cells displayed positive staining for vimentin, c-kit, CD34, and alpha smooth muscle actin. Ultrastructural examination of the rhabdoid tumor cells revealed paranuclear whorls of intermediate filaments, which were immunoreactive for vimentin by both light microscopic immunohistochemical and protein A gold immunoelectron microscopic techniques. On H&E light microscopic examination alone, such a tumor could be mistaken for a variety of epithelial, mesenchymal, or other neoplasms that may show rhabdoid features. One report of GIST with a rhabdoid histologic phenotype has been described. This is the second known report of such a case with immunophenotypic and ultrastructural evaluation, and the first case with immunoelectron microscopic examination.