High-resolution optical coherence tomography correlates in ischemic radiation retinopathy

Author： Raman Rajiv Pal Swakshyar Saumya Krishnan Tandava Laxmi Gella Radke Nishant Sharma Tarun

ISSN： 1556-9527

Source： Cutaneous and Ocular Toxicology (formerly Journal of Toxicology - Cutaneous and, Vol.29, Iss.1, 2010-03, pp. : 57-61

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Abstract

Purpose: To find the abnormalities in various retinal layers caused by radiation retinopathy using spectral domain optical coherence tomography (SD-OCT).Methods: We report a case of radiation retinopathy that was imaged using SD-OCT Copernicus (Optopol, Zawiercie, Poland). Analysis and synthesis of the OCT image were done using information both at the fovea and 2.5 mm temporal to the fovea.Results: The layers that were reduced in thickness included the inner plexiform layer (47 μm vs. 74 μm), the inner nuclear layer (17 μm vs. 48 μm), and the outer plexiform layer (25 μm vs. 45 μm), whereas the layers with comparable thickness included the nerve fiber layer (24 μm vs. 25 μm), the outer nuclear layer (42 μm vs. 43 μm), the outer segment–inner segment junction (52 μm vs. 54 μm), and the retinal pigment epithelium (RPE) choriocapillaris layer (30 μm vs. 28 μm).Conclusion: This report suggests that the radiation-induced damage was confined to the inner layers of the retina. However, secondary outer retinal layer changes may also occur, as suggested by functional derangements.