Author： Calistru Ana Maria Lisboa Carmen Cunha Ana Paula Bettencourt Herberto Azevedo Filomena
Publisher： Informa Healthcare
ISSN： 1556-9527
Source： Cutaneous and Ocular Toxicology (formerly Journal of Toxicology - Cutaneous and, Vol.31, Iss.3, 2012-09, pp. : 258-261
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Abstract
We report the case of a 22-year-old male patient with 2 episodes, 4 months apart, of acute generalized exanthematous pustulosis (AGEP) associated with oral intake of amoxicillin and simultaneous reactivation of parvovirus B19 infection proven by positive polymerase chain reaction test in the skin fragment and blood sample and elevation of the IgG antibodies titer. To our knowledge, this is the first report of AGEP resulting from the interaction between drug hypersensitivity and the reactivation of parvovirus B19. A combination of an immunological reaction to the drug and virus infection could be responsible for the clinical picture.
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