Author： Choo Yen
Publisher： Oxford University Press
ISSN： 1362-4962
Source： Nucleic Acids Research, Vol.26, Iss.2, 1998-01, pp. : 554-557
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
The paradigmatic DNA binding domain from the transcription factor Zif268 contains three zinc finger modules in tandem repeat. When bound to their cognate DNA site the fingers read out the sequence of one DNA strand by making a linear series of successive base contacts. It is shown that the base‐specific protein–DNA contacts made from the ends of the Zif268 three‐finger array contribute less to the stability of the intermolecular complex than do structurally equivalent contacts from more central regions of the DNA binding domain. The effect is akin to the end fraying observed in duplex nucleic acid molecules.
Related content
Access to resources
Recommend
Sequence-specific recognition of methylated DNA by human zinc-finger proteins
Nucleic Acids Research, Vol. 38, Iss. 15, 2010-08 ,pp. :