Author： Barrios Humberto Valderrama Brenda Morett Enrique
Publisher： Oxford University Press
ISSN： 1362-4962
Source： Nucleic Acids Research, Vol.27, Iss.22, 1999-10, pp. : 4305-4313
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Abstract
Promoters recognized by the RNA-polymerase with the alternative sigma factor 54 (E54) are unique in having conserved positions around –24 and –12 nucleotides upstream from the transcriptional start site, instead of the typical –35 and –10 boxes. Here we compile 186 –24/–12 promoter sequences reported in the literature and generate an updated and extended consensus sequence. The use of the extended consensus increases the probability of identifying genuine –24/–12 promoters. The effect of several reported mutations at the –24/–12 elements on RNA-polymerase binding and promoter strength is discussed in the light of the updated consensus.
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