Molecular basis for the enantioselectivity of HIV‐1 reverse transcriptase: role of the 3′‐hydroxyl group of the L‐()‐ribose in chiral discrimination between D‐ and L‐enantiomers of deoxy‐ and dideoxy‐nucleoside triphosphate analogs

Author： Maga Giovanni   Amacker Mario  

Publisher： Oxford University Press

ISSN： 1362-4962

Source： Nucleic Acids Research, Vol.27, Iss.4, 1999-02, pp. : 972-978

Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.

Previous Menu Next

Abstract

Related content

Arylsulfone-based HIV-1 non-nucleoside reverse transcriptase inhibitors

By Famiglini Valeria   Coluccia Antonio   Brancale Andrea   Pelliccia Sveva   La Regina Giuseppe   Silvestri Romano  

Future Medicinal Chemistry, Vol. 5, Iss. 18, 2013-12 ,pp. : 2141-2156

Future Science

Access to resources Recommend Favorite

Synthesis, Characterization, and Inhibitory Activities of Nucleoside alpha,beta-Imido Triphosphate Analogues on Human Immunodeficiency Virus-1 Reverse Transcriptase

By Li R.   Muscate A.   Kenyon G.L.  

Bioorganic Chemistry, Vol. 24, Iss. 3, 1996-09 ,pp. : 251-261

Academic Press

Access to resources Recommend Favorite

2'-Deoxy-4'-C-Ethynyl-2-Fluoroadenosine: A Nucleoside Reverse Transcriptase Inhibitor with Highly Potent Activity Against Wide Spectrum of HIV-1 Strains, Favorable Toxic Profiles, and Stability in Plasma

By Ohrui Hiroshi   Kohgo Satoru   Hayakawa Hiroyuki   Kodama Eiichi   Matsuoka Masao   Nakata Tomohiro   Mitsuya Hiroaki  

Nucleosides, Nucleotides & Nucleic Acids, Vol. 26, Iss. 10-12, 2007-10 ,pp. : 1543-1546

Taylor & Francis Ltd

Access to resources Recommend Favorite

Structural basis for activation of the therapeutic l-nucleoside analogs 3TC and troxacitabine by human deoxycytidine kinase

By Sabini Elisabetta   Hazra Saugata   Konrad Manfred   Burley Stephen K.   Lavie Arnon  

Nucleic Acids Research, Vol. 35, Iss. 1, 2007-01 ,pp. : 186-192

Oxford University Press

Access to resources Recommend Favorite

The Structure of N-(1-Deoxy-β-D-fructopyranos-1-yl)-L-proline Monohydrate ("D-Fructose-L-proline") and N-(1,6-Dideoxy-α-L-fructofuranos-1-yl)-L-proline ("L-Rhamnulose-L-proline")

By Mossine Valeri V.   Barnes Charles L.   Mawhinney Thomas P.  

Journal of Carbohydrate Chemistry, Vol. 26, Iss. 4, 2007-05 ,pp. : 249-266

Taylor & Francis Ltd

Access to resources Recommend Favorite