Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals

Author: Swayze Eric E.   Siwkowski Andrew M.   Wancewicz Edward V.   Migawa Michael T.   Wyrzykiewicz Tadeusz K.   Hung Gene   Monia Brett P.   Bennett and C. Frank  

Publisher: Oxford University Press

ISSN: 1362-4962

Source: Nucleic Acids Research, Vol.35, Iss.2, 2007-01, pp. : 687-700

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