Analysis of acyclic nucleoside modifications in siRNAs finds sensitivity at position 1 that is restored by 5-terminal phosphorylation both in vitro and in vivo

Author: Kenski Denise M.   Cooper Abby J.   Li Jenny J.   Willingham Aarron T.   Haringsma Henry J.   Young Tracy A.   Kuklin Nelly A.   Jones Jeffrey J.   Cancilla Mark T.   McMasters Daniel R.   Mathur Melina   Sachs Alan B.   Flanagan W. Michael  

Publisher: Oxford University Press

ISSN: 1362-4962

Source: Nucleic Acids Research, Vol.38, Iss.2, 2010-01, pp. : 660-671

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Abstract