Author: Yamada Kazumasa Inagaki Tsuyoshi Funahashi Rie Yoshimura Yumiko Komatsu Yukio
Publisher: Oxford University Press
ISSN: 1460-2199
Source: Cerebral Cortex, Vol.16, Iss.9, 2006-09, pp. : 1239-1248
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Abstract
Long-term potentiation (LTP) at inhibitory synapses of rat visual cortex requires firing of presynaptic cells for maintenance, at least at a low frequency. We examined the roles of adrenoceptors in this LTP maintenance. Although high-frequency stimulation (HFS) failed to produce LTP in normal Ca2+ medium, it produced pathway-specific LTP with addition of noradrenaline to the medium soon after HFS. However, this LTP disappeared after washout of noradrenaline. HFS applied during noradrenaline application produced LTP persisting even after washout, indicating that HFS together with adrenoceptor activation makes the adrenergic facilitation enduring. After washout, LTP was produced further by HFS of the conditioned, but not the unconditioned, pathway by the first HFS. Pharmacological examination demonstrated that α
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