Author： Helmstaedter Moritz Sakmann Bert Feldmeyer Dirk
Publisher： Oxford University Press
ISSN： 1460-2199
Source： Cerebral Cortex, Vol.19, Iss.4, 2009-04, pp. : 951-962
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Abstract
For a detailed description of the circuitry of cortical columns at the level of single neurons, it is essential to define the identities of the cell types that constitute these columns. For interneurons (INs), we described 4 types of axonal projection patterns in layer 2/3 (L2/3) with reference to the outlines of a cortical column (Helmstaedter et al. 2008a). In addition we quantified the dendritic geometry and electrical excitability of 3 types of the L2/3 INs: local, lateral, and translaminar inhibitors (Helmstaedter et al. 2008b). Here, we used an iterated cluster analysis (iCA) that combines axonal projection patterns with dendritic geometry and electrical excitability parameters to identify groups of INs, from a sample of 39 cells. The iCA defined 9 groups of INs. We propose a hierarchical scheme for identifying L2/3 INs. First, L2/3 INs can be classified as 4 types of axonal projections. Second, L2/3 INs can be subclassified as 9 groups with a high within-group similarity of dendritic, axonal, and electrical parameters. This scheme of identifying L2/3 INs may help to quantitatively describe inhibitory effects on sensory stimulus representations in L2/3 of cortical columns.
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