Misoprostol moistened with acetic acid or saline for second trimester pregnancy termination: a randomized prospective double-blind trial

Author： Yilmaz Bulent   Kelekci Sefa   Ertas Ibrahim Egemen   Kahyaoglu Serkan   Ozel Murat   Sut Necdet   Danisman Nuri  

Publisher： Oxford University Press

ISSN： 1460-2350

Source： Human Reproduction, Vol.20, Iss.11, 2005-11, pp. : 3067-3071

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Abstract

BACKGROUND: This study was conducted to evaluate the efficacy and side effects of a new regimen of 800 µg misoprostol administered intravaginally every 6 h up to a maximum of three doses in 24 h for second trimester pregnancy termination. METHODS: A total of 66 women seeking termination of second trimester pregnancy (30 fetal structural anomaly, six chromosomal abnormality and 30 fetal death) were randomly assigned to one of two treatment groups: (i) intravaginal misoprostol moistened with 3 ml of 5% acetic acid in group A (n = 33); or (ii) intravaginal misoprostol moistened with 3 ml of saline in group B (n = 33). RESULTS: The overall median (range) induction–abortion interval was 10 h (2–46) [10 h (4–35) in 36 live fetuses and 9 h (2–46) in 30 dead fetuses, P = 0.515]. All of the patients in both groups aborted within 48 h (100% success rate). The median (range) induction–abortion interval revealed a significantly faster delivery time (P < 0.001)="" in="" group="" a="" [8="" h="" (2–24)]="" than="" in="" group="" b="" [14="" h="" (3–46)].="" conclusions:="" this="" new="" regimen="" of="" 800="" µg="" of="" vaginal="" misoprostol="" every="" 6="" h="" for="" a="" maximum="" of="" three="" doses="" in="" 24="" h="" was="" an="" effective="" alternative="" method="" for="" second="" trimester="" abortion.="" in="" addition,="" misoprostol="" moistened="" with="" acetic="" acid="" was="" significantly="" more="" effective="" than="" misoprostol="" moistened="" with="" saline.="">

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